Transgenic Core Facility
About Us
The Transgenic Core Facility (CCMR TCF), being a part of the Centre for Comparative Medicine Research, supports the LKS Faculty of Medicine in research by not only preserving valuable transgenic mouse lines through embryo/sperm cryopreservation, and re-derivation and rescue of mouse colonies using assisted reproductive technology; but also generation of novel transgenic and gene targeted mice for researchers to study various disease models. The facility also maintains a repository of reagent mouse lines for principal investigators to generate mutant/ transgenic mice in research to study disease pathogenesis and gene interaction in vivo. The mission of TCF is to provide an efficient centralized service to support the HKU’s cutting-edge research involving genetically modified animals.
Transgenic Core Facility (TCF) provides centralized services including mouse strain archive and gene editing. We provide services on embryo/sperm cryopreservation, in-vitro fertilization (IVF), and embryo/sperm rederivation of mouse colonies. To generate genetically modified animals, we provide pronuclear DNA injection (transgenesis), and ES cell-morula injection. Furthermore, we also provide gene edition services, e.g. indel, point mutation, and Knock-In by using CRISPR/Cas9. Collaboration with new or specific technical development is also welcome.
We maintain a repository of reagent mouse lines for principal investigators to generate mutant/ transgenic mice in research to study disease pathogenesis and gene interaction in vivo. The available reagent mouse strains are as below.
List of Reagent / Genetically Modified Mouse Strains
For Service request, please complete the form by clicking the link below. Our staff will contact you within 3 working days after you submit this form. You will be required to provide further information and we will process your request once we receive all supplementary information. Please use hku portal account to login.
TCF Service Request form
Price List
For enquiry, please contact us at tcfccmr@hku.hk
