Technical Services & Equipment
Equipment
UltraFocus fully-shielded x-ray cabinet
LocationCA-DMB: Room EG23, G/F, Dexter H.C. Man Building, 8A Sassoon Road
Description
UltraFocus is a fully shielded x-ray cabinet offering a large field of view and ultra high-resolution for imaging a broad range of biological and light Non-Destructive Testing (NDT) samples.
Application
1. Clinical Assessment
2. Pre-clinical Imaging of biological samples (in vivo or ex vivo)
3. Forensic Imaging
Documents and manuals
Faxitron UltraFocus Manual
Faxitron UltraFocus SOP
Booking
Application for training: Apply Now
Facility online booking: Apply Now
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
IVIS Lumina X5
LocationCA-DMB: Room E223, 2/F, Dexter H.C. Man Building, 8A Sassoon Road
Description
The IVIS Lumina X5 imaging system is a non-invasive, real-time in vivo imaging system allowing longitudinal assessment in living animals at multiple time points. This system can measure both bioluminescence and fluorescence signals with high sensitivity. The system also integrated with high resolution low dose x-ray, with optical image overlay allowing study the underlying anatomical and structural changes. Moreover, IVIS X5 equipped with 26 tunable filters allow to detect fluorescence from the visible spectrum through the Near Infra-Red spectrum. The high-throughput imaging enables rapid signal capturing up to five mice simultaneously.
Application
1. Biological effects and therapeutic effectiveness of drug/vaccine candidates
2. Replication or transmission of viruses or bacteria
3. Neurodegenerative disease research
4. Oncolytic viral infection in living tumors
5. Tumor-induced bone erosion research
6. Tumor development
Documents and manuals
IVIS Lumina X5 Manual
IVIS Lumina X5 Software Manual
IVIS Lumina X5 SOP
IVIS Lumina X5 General Conditions and terms
Booking
Application for training: Apply Now
Facility online booking: Apply Now
| Single session booking time | 0.5 to 3 hours |
| Advanced booking | Pre-booking up to 14 days |
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
IVIS Spectrum
LocationCA-FMB: Room AR6, R/F, Li Ka Shing Faculty of Medicine Laboratory Block, 21 Sassoon Road
Description
IVIS Spectrum is an advanced pre-clinical optical imaging system which facilitates non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals. Quantitative monitoring of both bioluminescent and fluorescent reporters across the blue to almost infrared wavelength spectrum is possible. It can also create 3D tomography images that permit source localization and concentration, as well as anatomical analysis using a 3D mouse atlas in software.
Application
1. Tumor development monitoring or with bioluminescent reporter (e.g. Firefly luciferase)
2. Microbiological infection tracking with fluorescent reporter (e.g. GFP, mCherry)
3. Pharmacokinetics/pharmacodynamics
4. in vivo and ex vivo inflammation, cardiovascular, neurology, respiratory and stem cell research
Documents and manuals
IVIS Spectrum Configuration Detail
Booking
Application for training: Apply Now
Facility online booking: Apply Now
Note: Please reserve the Biosafety Cabinet / Cage Changing Station at the same time
| Single session booking time | 0.5 to 3 hours |
| Advanced booking | Pre-booking up to 28 days |
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
Bruker MALDI Biotyper Sirius
LocationDSD Laboratory: Room 108, LG1/F, Dexter H.C. Man Building, 8 Sassoon Road
Description
The Bruker MALDI Biotyper Sirius identifies microorganisms using Matrix-Assisted Laser Desorption Ionization/ Time of flight (MALDI-TOF) Mass Spectrometry to determine the unique proteomic fingerprint of an organism.
Application
Turnaround Time: 1-3 working days
*TAT depends on the purity of the cultured sample. Do not refrigerate cultures. Receipt of cultures ^not meeting these criteria will delay turnaround time
Booking
For enquires, please contact: Ms. Candy Ho, hocandy@hku.hk/ dsdccmr@hku.hk
Cancellation Policy
1. User should call 3910-2050 or email to cancel sample submission as early as possible if testing is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
PLI-90A Pico-liter Microinjector with Nikon SMZ745T/SMZ800 Microscope
LocationZebrafish core facility: 6/F, Li Ka Shing Faculty of Medicine Laboratory Block, 21 Sassoon Road
Description
- PLI-90A picoinjector
The PLI-90A picoinjector reliably delivers injections from femtoliters to nanoliters through micropipettes by applying a regulated pressure for a digitally set period of time. Pressure to the pipette is controlled precisely through a multi-turn regulator and is reported digitally for reproducibility. Injection time is set using an optically encoded circuit that permits both fine and coarse settings from a single control knob. System timing can be controlled in three ways: push button, foot switch, or external trigger.
-SMZ745T Microscope
The SMZ745T Features a zoom magnification of 7.5X and a long working distance of 115mm, Nikon SMZ745 microscopes are well suited for both industrial and biomedical applications. The adoption of a new total reflection prism produces brighter images with higher contrast, and the anti-mold design allows the microscope to be used in environments where the temperature and humidity are high.
-SMZ800 Microscope
The SMZ800N offers higher magnification than conventional models, enabling high-resolution observation of minute structures. In combination with the new objective series, its improved chromatic aberration correction provides bright and sharp images through the entire viewfield. The parallel optics design allows ergonomic accessories and observation attachments to be used in a wide range of applications.
Application
1. Zebrafish embryo injection
2. Xenopus embryo injection
Documents and manuals
Microinjection Calibration Chart
Microinjection Calibration Chart SOP
Booking
Application for training: Apply Now
Facility online booking: Apply Now
| Single session booking time | 0.5 to 3 hours |
| Advanced booking | Pre-booking up to 14 days |
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
Nanoject III - Hydraulic Nanoliter Injection System
LocationCA-DMB: 2/F. Dexter Man H.C. building, 8 Sassoon Road
Description
The Nanoject III Nanoliter Injector offers a number of state-of-the-art features to provide easy setup and operation as well as more accurate injection volumes down to 0.6 nanoliters. The Nanoject III does not require any O-rings to secure the micropipette, instead using a micro chuck that allows easy attachment of the micropipette once backfilled with oil.
Operational Modes enable the user to program the unit to do single manual injections, as well as multiple injection cycle recipes. Program input and execution is enabled by prompted touchscreens located on the control box. Programmability, the lower injection volume capability plus the user's ability to select the injection rate widens the potential range of Application for the Nanoject III compared to its predecessor.
Application
1. Zebrafish embryo injection
2. Xenopus embryo injection
Documents and manuals
Nanoject III Manual
Booking
Please contact zcorefac@hku.hk
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
Nikon Stereo Microscope SMZ1270 SMZ25
LocationZebrafish core facility: 6/F, Li Ka Shing Faculty of Medicine Laboratory Block, 21 Sassoon Road
Description
-SMZ1270
The SMZ1270 series exceeds the standard imaging requirements for observing and recording minute object features. The extended zoom ratio of 12.7:1 combines ease-of-use with excellent optical performance.
The nosepiece enables observation over a huge magnification range. Two objectives extend the magnification range without moving the sample. An on-axis vertical view allows plan imaging of holes or pin structures without a tilted viewpoint. Integration with Nikon's NIS-Elements software suite, enables capture of live magnification data. The intelligent double objective nosepiece also reports the magnification of the objective lens used.
-SMZ25
The SMZ25 features a Perfect Zoom System which provides zoom ratio of 25:1 (zoom range: 0.63x - 15.75x). Even with a 1x objective lens, the SMZ25 captures the entire 35mm dish and simultaneously delivers microscopic details.
Perfect Zoom System dynamically changes the distance between the two optical axes as the zoom factor is changed. This change in optical axis distance enables maximization of light entry into the optical system at every magnification. The result is an uncompromised, large zoom range, high resolution in both eye paths, and minimal aberrations over the entire zoom-range.
The SMZ25 series use a fly-eye lens on an epi-fluorescence attachment which ensures bright and uniform illumination even at low magnifications, resulting in uncompromised uniformity in brightness across a large field of view.
The newly developed optical system with improved S/N ratio makes it possible to capture low fluorescence signals and light-sensitive events such as cell division, which is difficult using conventional stereo microscopes.
Application
1. Zebrafish embryo injection
2. Xenopus embryo injection
3. Zebrafish dissection
Documents and manuals
Research Stereo Microscope SMZ1270 Manual
Research Stereo Microscope SMZ25 Manual
Booking
Please contact zcorefac@hku.hk
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
P-1000 Micropitpette Puller
LocationZebrafish core facility: 6/F, Li Ka Shing Faculty of Medicine Laboratory Block, 21 Sassoon Road
Zebrafish core facility: 2/F. Dexter H.C. Man building, 8 Sassoon Road
Description
P-1000 is a Micropitpette Puller incorporated with extensive library of programs. You need only specify the glass, filament, and type of pipette you require and a suitable program will be identified and available for installation.
New features for the P-1000 include: diagnostic testing of all puller components, built-in error detection of air pressure loss or filament burnout, easy access to ramp test, measurement of jaw temperature, and access to previous pull results with the heat on times for each cycle of the program.
Application
1. Zebrafish embryo injection
2. Xenopus embrryo injection
3. Pronuclear injection
Documents and manuals
P-1000 Cookbook
P-1000 Operation Manual
P-1000 Quick Start Guide
Booking
Application for training: Apply Now
Facility online booking: Apply Now
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
RWD Veterinary Inhalation Anesthesia Machine
LocationCA-DMB: G/F, 2-3/F, Dexter H.C. Man Building, 8A Sassoon Road
CA-FMB: R/F, Li Ka Shing Faculty of Medicine Laboratory Block, 21 Sassoon Road
Description
The Enhanced animal veterinary anesthesia machine is designed for safe, simple, and controllable inhalation anesthesia with Isoflurane (Easy fill), Active gas evacuations and Oxygen concentrator as gas supply.
Application
For rat, mouse, rabbit, hamster, gerbils and Guinea pig and other animals within 7kg
Documents and manuals
RWD Anesthesia Machine SOP
Booking
Application for training: Apply Now
Facility online booking: Apply Now
| Single session booking time | 0.5 hours |
| Advanced booking | Pre-booking up to 1 days |
- Please reserve a procedure room or Biosafety Cabinet at the same time.
- For training, please contact technical staff 7 days in advance.
- The machine can only be used within CA-DMB area.
Contact: dmbccmr@hku.hk
CA-FMB notes:
- Please reserve a procedure room or cage changing station if needed.
- For training, please contact technical staff 2 days in advance.
- The machine can only be used within CA-FMB area.
Contact: fmbccmr@hku.hk
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
Siemens X-Ray Mobilett Mira Max
LocationCA-DMB: Room EG23, G/F, Dexter H.C. Man Building, 8A Sassoon Road
Description
The Siemens Mobilett Mira Max is a fully digital mobile X-ray machine that helps to speed up the examination workflow. It makes mobile X-ray imaging effortless and fast, and with its powerful generator and MAX detectors provides outstanding image quality in seconds.
Achieve mobile X-ray process efficiency with a digital companion that offers fast and reliable imaging results.
Application
1. Clinical Assessment
2. Pre-clinical Imaging of biological samples (in vivo or ex vivo)
3. Forensic Imaging
Documents and manuals
Siemens Mobilett Quick Guide
Siemens Mobilett SOP
Booking
Please contact dmbccmr@hku.hk
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
TumorImager 2TM & TumorManagerTM
LocationCA-DMB: Room E214, 2/F, Dexter H.C. Man Building, 8A Sassoon Road
Description
The Tumorlmager is a High Throughput Subcutaneous Tumor Measurement & Tracking System (TMS).
The whole Tumor Management System consists of two parts:
1. TumorImager 2: it is a 3D scanning device for tumour measurement.
2. TumorManager: it is a software for xenograft study management.
It uses a unique structured light imaging system to capture both a 3D surface profile and a colour image.
Application
1. Measure and record subcutaneous tumour volume (single tumour) of small laboratory animals.
2. Measure and record body weight of small laboratory animals
3. Produce summary report of the tumour study.
Documents and manuals
Tumour Manager SOP
Booking
Application for training: Apply Now
Facility online booking: Apply Now
Note: Please reserve the Biosafety Cabinet / Cage Changing Station at the same time
| Single session booking time | 0.5 to 3 hours |
| Advanced booking | Pre-booking up to 14 days |
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
Ultrasound scanner portable
LocationCA-DMB: Dexter H.C. Man Building, 8A Sassoon Road
CA-FMB: R/F, Li Ka Shing Faculty of Medicine Laboratory Block, 21 Sassoon Road
Description
The Mindray TE7 ACE is designed to cover the Anesthesia, Critical Care and Emergency applications. It provides smart fluid management tools, safe needling features, a complete disinfection solution, and superior quality imaging.
Application
1. Clinical Assessment
2. Pre-clinical Imaging of biological samples (in vivo or ex vivo)
Documents and manuals
Mindray Diagnostic Ultrasound System TE7 SOP
Booking
Application for training: Apply Now
Facility online booking: Apply Now
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
R&D Aquatics DC-96 Genotyping Rack and Tank
LocationCA-DMB: Dexter H.C. Man Building, 8A Sassoon Road
Description
The DC-96 allows researchers to house 24 individual fish in less than 4 tank spaces while still allowing fish to have more than 0.2L of water in each compartment. The DC-96 offers reserachers to keep fish in the system.
Application
The DC-96 is ideal for holding fish while fin clips are processed for: traditional genotyping, KASP (Kompetitive Allele Specific PCR) assays, ID'ing Zinc Finger Nuclease (ZFN), and Transcription Activator-Like Effector Nuclease (TALEN) mutant carriers, or new transgenic carriers, and any other procedure that requires keeping individual fish separate from the rest of a population.
By removing dividers you can easily double the size of the holding compartment to accommodate a pair of zebrafish. This arrangement is ideal for holding pairs while embryos are screened for phenotypic defects or transgenic expression. In addition to routine screening experiments, the DC-96 is an excellent choice for housing pairs during ENU mutagenesis screens.
Documents and manuals
R&D Aquatics Website
Booking
Please contact zcorefac@hku.hk
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
Tecniplast iSPAWN-S
LocationCA-DMB: Dexter H.C. Man Building, 8A Sassoon Road
Description
This fish breeding system has a water capacity of 13L and can accommodate up to 20 couples of fish. It is designed to efficiently collect a large number of synchronized embryos within a defined window of time, with minimal labor and space requirements. The system can be set up either as static or recirculating. It is also designed to mimic the natural spawning of Zebrafish, promoting fish mating behavior.
Documents and manuals
Tecniplast Website
Booking
Please contact 3910 2050 to inquire service availability prior to sample submission
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
Sysmex Haematology Analyzer XN-1000V
LocationCA-DMB: Dexter H.C. Man Building, 8A Sassoon Road
Description
Introducing the Sysmex XN-V Series, a powerful equipment that enables you to deliver diagnostic results of the highest quality and value. The XN-1000V, known for its consistent reliability and secure results, can be easily customized or scaled up to meet your evolving needs.
Recognizing the diverse requirements of diagnostic information across various species, we have conveniently preloaded 19 commonly tested animal species. Moreover, you have the flexibility to define your own settings, whether for research purposes or to enhance diagnostic value. With the assurance of online quality control, you can trust that your new analyzer will consistently deliver reliable and efficient results.
Additionally, the Sysmex XN-V Series offers advanced features such as optical platelet count, reticulocyte parameters, and body fluid analysis, providing valuable diagnostic insights whenever necessary.
Application
| Species | Mouse, rat, dog, NHP, rabbit, cat, horse, cattle, pig, mini pig, Guinea pig, gerbil, camel, dolphin, marmoset, ferret, sheep, goat, hamster, bird |
| Standard parameters | XN-CBC
WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, RDW-SD, RDW-CV, PDW, MPV, P-LCR, PCT, NRBC %, NRBC#, MicroR*, MacroR* XN-DIFF NEUT%, NEUT#, LYMPH%, LYMPH#, MONO%, MONO#, EO%, EO#, BASO%, BASO# |
Documents and manuals
Product Document
Sysmex Product Webpage
Booking
Blood Sample Submission Form: Download Here
Please contact 3910 2050 to inquire service availability prior to sample submission.
Cancellation Policy
1. User should cancel the booking as early as possible if the booking is no longer required.
2. A service and administrative fees will be charged if you do NOT show up for your reservation, late arrival and do NOT cancel in advance.
Photos
